ReplyData regarding anaphylaxis-related deaths in England and Wales is documented by the Office for National Statistics (ONS). The British Society for Allergy and Clinical Immunology also holds a register to capture and learn from fatal cases of anaphylaxis, the UK Fatal Anaphylaxis Register, which has been operational since 1992.The following table shows the number of deaths in England and Wales where fatal anaphylactic reactions were reported as the underlying cause of death:Registration YearDeaths20141,42920151,59820161,56320171,64620181,73120191,59720201,67420211,46520221,64520231,665Source: ONS The following table shows the number of deaths in England and Wales where fatal anaphylactic reactions were mentioned on the death certificate:Registration yearDeaths20148,11220158,17020168,32420178,58020188,45520198,259202011,379202110,97220228,87920238,645Source: ONS